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One of the best ways to study human evolution is by comparing us with nonhuman species that, evolutionarily speaking, are closely related to us. That closeness can help scientists narrow down precisely what makes us human, but that scope is so narrow it can also be extremely hard to define. To address this complication, researchers from Stanford University have developed a new technique for comparing genetic differences.
Through two separate sets of experiments with this technique, the researchers discovered new genetic differences between humans and chimpanzees. They found a significant disparity in the expression of the gene SSTR2 - which modulates the activity of neurons in the cerebral cortex and has been linked, in humans, to certain neuropsychiatric diseases such as Alzheimer s dementia and schizophrenia - and the gene EVC2, which is related to facial shape. The results were published March 17 in
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Romanian-born M.D. Sergiu Pasca of the Stanford University was named 2021 Basic Research Awardee by the Schizophrenia International Research Society (SIRS).
According to SIRS President, Dame Til Wykes, the award goes to a SIRS member who has made an outstanding basic research contribution to schizophrenia research.
Dr. Sergiu Pasca is an Associate Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University and the Bonnie Uytengsu and Family Director of Stanford Brain Organogenesis.
Interested in understanding the rules governing brain assembly and the mechanisms of disease, he developed some of the initial in-a-dish models of disease by deriving neurons from skin cells taken from patients with genetic neurodevelopmental disorders. He also pioneered a modular system to integrate 3D brain region-specific organoids and study migration and neural circuit formation in functional preparations known as assembloids.
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Testimonials .I don t believe it. Having been giving a great deal of help and support from the AboutMyArea team, I have become the sub-editor of the Hamworthy Matters pages of the AboutMyArea - Poole. There. more .I don t believe it. Having been giving a great deal of help and support from the AboutMyArea team, I have become the sub-editor of the Hamworthy Matters pages of the AboutMyArea - Poole. There is no doubt, if I can do it - anyone can! Why not give it a try and also become a Contributor?
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Shasqi, a clinical-stage biotechnology company developing precision activated oncology therapeutics with its proprietary Click Activated Protodrugs Against Cancer (CAPAC
TM) platform, announced today the members of its strategic advisory board, which bring a range of expertise to the company including corporate strategy, clinical development, cellular biology, and cancer therapeutics.
“Shasqi has made important progress during the last year with the initiation of our phase 1 clinical trial of SQ3370 and the advancement of our CAPAC drug development platform we’re preparing for the next phase of our growth,” said José M. Mejía Oneto, M.D., Ph.D., Founder and CEO of Shasqi. “We’ve deliberately selected and cultivated a team of strategic advisors with the skills, expertise and experience to help us navigate through the opportunities ahead of us and, ultimately, position us to benefit as many peop