Global building materials supplier Cemex is strengthening its commitment to Health and Safety by implementing new safety assistance systems across all its European Admixtures facilities. This techn.
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Credit: CNIO
Researchers from the Microtubule Organization lab, headed by Jens Lüders at IRB Barcelona, and the Macromolecular Complexes in DNA Damage Response Group, led by Oscar Llorca at the Spanish National Cancer Research Centre (CNIO), have achieved the first in vitro reconstitution of the human -tubulin ring complex (γTuRC), responsible for initiating microtubule formation. In addition, they revealed its 3D structure by cryo-electron microscopy. The key to their success lies in the identification of the RUVBL protein complex as an essential γTuRC assembly helper.
Microtubules are a component of the cytoskeleton, which is essential for intracellular transport processes and cell division. Microtubules cannot form spontaneously in cells but require nucleation by the γTuRC. Mutations in γTuRC subunits cause neurodevelopmental defects such as microcephaly and have also been linked to defects in the retina.
Scientists assemble the gamma-tubulin ring complex in vitro for the first time phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.