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Study uncovers cryptic vulnerabilities in RET oncogene that could aid in anti-cancer drug design

RET is a receptor protein with tyrosine kinase activity that can transfer a phosphate group from ATP to other molecules modifying their shape and function in signaling pathways that are essential to organogenesis and tissue maintenance.

Ivan plaza menachoEmily hendersonCancer groupSpanish national cancer research centreExperimental therapeutics programmeProtein phosphorylation

Patient Biopsy Screening Platform Identifies Potential Drug Candidates against Brain Metastases

CNIO researchers claim the new METPlatform is simple, fast, cheap, and “infinitely superior to other screening methods.”

Manuel valienteNational cancer research centreExperimental therapeutics programmeBrain metastasis group

New METPlatform allows researchers to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

Castilla la manachaComplejo hospitalario universitarioCunqueiro complejo hospitalarioEva ortega paManuel valienteEmily hendersonNational cancer research centreSpanish ministry of scienceBreast cancer clinical research unitCancer research instituteHealth instituteNational brain metastasis networkMelanoma research allianceWorldwide cancer researchExperimental therapeutics programmeBrain metastasis group

Repressing a protein that facilitates DNA repair to potentiate chemotherapy

Repressing a protein that facilitates DNA repair to potentiate chemotherapy
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United statesLuis blancoSevero ochoaEmily hendersonReplication groupExperimental therapeutics programmeWashington university st louisCentro de biologMolecular severo ochoaWashington universityTherapeutics programmeஒன்றுபட்டது மாநிலங்களில்லூயிஸ் ப்ளான்க்கோசேவேரோ ஆசோவஎமிலி ஹென்டர்சன்பிரதிசெய்கை குழு

CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy

CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy
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United statesLuis blancoSelena blancoMassimo lopesSevero ochoaPatricia ubietoDaniel gonzEuropean regional development fundSpanish ministry of scienceReplication groupUniversity of zurich switzerlandExperimental therapeutics programmeWashington university st louisSwiss national science foundationEuropean research councilNational institute of health carlos