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Research led by scientists at Children s Cancer Institute and published this week in the international journal,
Clinical Cancer Research, has found a combination of therapies that appears to be highly effective against high-risk neuroblastoma and other forms of aggressive childhood cancer.
Up to half of all cases of neuroblastoma newly diagnosed in children are high-risk , meaning the cancer grows aggressively and is difficult to treat. Despite receiving intensive treatment, most children with high-risk disease die within five years of diagnosis, while those who survive are often left with serious long-term health effects.
Professor Michelle Haber AM, a senior author on the paper and co-head of the Molecular Targets and Cancer Therapeutics theme at Children s Cancer Institute, said children diagnosed with high-risk neuroblastoma have less than a 50-50 chance of survival. That is a devastating prognosis. We are absolutely determined to find better ways to treat this
Study finds multimodal therapy may hold key to treating aggressive childhood cancer aninews.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from aninews.in Daily Mail and Mail on Sunday newspapers.
Study may lead to new treatment for incurable brain cancer in children
Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 20 children in Australia each year, DIPG is a devastating disease with an average survival time of just nine months after diagnosis.
The research, led by scientists at Children s Cancer Institute and published this week in the international journal,
Cell Reports, offers an exciting new therapeutic approach for the treatment of DIPG by using a new anti-cancer drug.
The new drug, CBL0137, is an anti-cancer compound developed from the antimalarial drug quinacrine. The researchers found that CBL0137 directly reverses the effects of the key genetic drivers in DIPG, and has a profound effect against DIPG tumor models.
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Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 20 children in Australia each year, DIPG is a devastating disease with an average survival time of just nine months after diagnosis.
The research, led by scientists at Children s Cancer Institute and published this week in the international journal,
Cell Reports, offers an exciting new therapeutic approach for the treatment of DIPG by using a new anti-cancer drug.
The new drug, CBL0137, is an anti-cancer compound developed from the antimalarial drug quinacrine. The researchers found that CBL0137 directly reverses the effects of the key genetic drivers in DIPG, and has a profound effect against DIPG tumour models. They also foundCBL0137 is even more effective when combined with a second drug, panobinostat, a new type of drug known as a histone deacetylase (HDAC) inhibitor. When used