Multigenerational households are on the rise in Colorado and across the United States. Due to high housing and medical costs, the share of the American population living in multigenerational homes has more than doubled over the past five decades, according to Pew Research, from 7% in 1971 to 18% in 2021.
Objective To assess the clinical and cost effectiveness of conservative management compared with laparoscopic cholecystectomy for the prevention of symptoms and complications in adults with uncomplicated symptomatic gallstone disease.
Design Parallel group, pragmatic randomised, superiority trial.
Setting 20 secondary care centres in the UK.
Participants 434 adults (>18 years) with uncomplicated symptomatic gallstone disease referred to secondary care, assessed for eligibility between August 2016 and November 2019, and randomly assigned (1:1) to receive conservative management or laparoscopic cholecystectomy.
Interventions Conservative management or surgical removal of the gallbladder.
Main outcome measures The primary patient outcome was quality of life, measured by area under the curve, over 18 months using the short form 36 (SF-36) bodily pain domain, with higher scores (range 0-100) indicating better quality of life. Other outcomes included costs to the NHS, quality adjuste
From Steamboat Springs to Salida, western Colorado residents say they rely on the postal service as never before because Amazon and other delivery trucks often don't deliver in mountain areas. But delivery remains a serious problem