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UCSD: Drug Paring Shows Promise Against Pancreatic Cancer

In the fight against pancreatic cancer, a combination of drugs outperformed other treatments in human cell and mouse models, and should be used in human clinical trials, UC San Diego researchers announced Wednesday.

New molecular pathway critical to the initiation of pancreatic tumors discovered

Tumor Initiation Driven by Stress-Resistant Cells in Pancreas

Tumor Initiation Driven by Stress-Resistant Cells in Pancreas
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Therapy sneaks into hard layer of pancreatic cancer tumor and destroys it from within

 E-Mail IMAGE: Andrew Lowy, MD, is the co-corresponding author of the study, professor of surgery at UC San Diego School of Medicine and chief of the Division of Surgical Oncology at Moores. view more  Credit: UC San Diego Health Sciences Every 12 minutes, someone in the United States dies of pancreatic cancer, which is often diagnosed late, spreads rapidly and has a five-year survival rate at approximately 10 percent. Treatment may involve radiation, surgery and chemotherapy, though often the cancer becomes resistant to drugs. Researchers at University of California San Diego School of Medicine and Moores Cancer Center, in collaboration with Sanford-Burnham-Prebys Medical Discovery Institute and Columbia University, demonstrated that a new tumor-penetrating therapy, tested in animal models, may enhance the effects of chemotherapy, reduce metastasis and increase survival.

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