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Date Time Genetic differences important for Alzheimer’s diagnosis The two used methods for detecting amyloid pathology in Alzheimer’s disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs. Arianna Sala, currently a post-doctoral fellow at the University of Liège, Belgium and Technical University of Munich, and first author. Photo: Francesco Ciurlo. Alzheimer’s disease is the most common dementia disease and leads to gradual memory loss and premature death. Approximately 120,000 people in Sweden have Alzheimer’s and there are approximately 50 million people worldwide. According to Hjärnfonden, the number will increase by 70 percent in 50 years, partly because we are living longer and longer.

Karolinska institutetArianna salaElena rodriguez vieitezFrancesco ciurloAgneta nordbergAmit kumarDementia foundationWiberg foundationDepartment of neurobiologyBrain foundationUniversity of liFoundation for strategic researchTechnical university of munichSwedish research councilEuropean union innovative medicines initiativeAlzheimer foundation