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Rayne Zaayman-Gallant/EMBL In the early days of the COVID-19 pandemic, it was established that SARS-CoV-2 infects cells by binding to the human protein ACE2, which plays a role in regulating blood pressure. But ACE2 is almost absent in human lung cells, so how can the lungs be one of the most affected organs in COVID-19? This gave researchers a hint that ACE2 might be more than just a blood pressure regulator, and might not be the only player in the SARS-CoV-2 infection mechanism. The European Molecular Biology Laboratory (EMBL s) Gibson team, in collaboration with Lucía Chemes at Universidad Nacional de San Martín in Buenos Aires and partners from Merck KGaA Darmstadt and University College Dublin, analyzed sequences of ACE2 and other human proteins involved in SARS-CoV-2 infection, such as a class of proteins called integrins. They focused on short strings of amino acids called short linear motifs (SLiMs), which are involved in transmitting information between the inside and ou

Baden wubergBuenos airesDistrito federalUppsala lanManjeet kumarElizabeth martToby gibsonYlva ivarssonMerck kgaa darmstadtRayne zaaymanUppsala universityLeloir instituteUniversity college dublinEuropean molecular biology laboratoryProtein sequences provide cluesUniversidad nacional de san mart