Has anyone ever wondered how cutting-edge technologies are reshaping the landscape of healthcare, particularly in the analysis of blood results? In your world, a blood test can provide you with valuable health insights and can be performed conveniently from your home. In this article, we explore the transformative journey where technology meets healthcare, paving the
Two candidates are running for a four-year term as Ward 5 representative on Geneva City Council: Wil Wolf, who is running on the Democratic and Geneva Forward party lines, and
Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the release of mitochondrial DNA (mtDNA) into the cytosol. Cytosolic mtDNA in turn activates the cGAS–STING pathway, a major regulator of the SASP. We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar mitochondria-depende
China's Ministry of Science and Technology issued the "Detailed Rules for the Implementation of the Regulations on the Management of Human Genetic Resources" on June 1. The detailed rules stipulate that the collection, preservation, utilization and external provision of Chinese genetic resources shall comply with ethical principles and pass the ethical review of the ethics (review) committee that has been filed with the relevant management departments. The rules are formulated in accordance with the "Biurity Law of the People's Republic of China" and other relevant laws and administrative regulations.