th June, 2021.
1.5.
Geographical Location: 28 counties of Kenya (Bungoma, Busia, Elgeyo Marakwet, Garissa, Homa bay, Kajiado, Kakamega, Kiambu, Kilifi, Kisumu, Kitui, Kwale, Lamu, Mandera, Marsabit, Mombasa, Muranga, Narok, Nyamira, Samburu, Siaya, Taita Taveta, Tana River, Trans Nzoia, Turkana, Vihiga, Wajir and West Pokot).
1.6.
1.7.
1.8.
1.9.
2.
Background Information
The Kenya Red Cross Society (KRCS) is the non-state Principal Recipient (PR) for the Global Fund HIV Grant, focussing on creating demand for health services from the community through increasing access to community HIV testing and counselling; expanding services for HIV prevention; providing community HIV care and support and strengthening community health systems. The KRCS is committed to ensuring that the vulnerable communities in the country have access to much needed services in the most efficient, effective, reliable and trusted manner at any time and whenever required.
G,
H) for both HT29DDP and HCT116-LOHP cells. The graphs of b, d, f. and h are the densitometry results of corresponding WB assays.
Notes: P 0.05; P 0.01.
Combination Treatment Promoted Apoptosis in Drug-Resistant Colon Cancer Cells
We further analyzed the effect of combinational therapy on apoptosis of colon cancer cells. The results (Figure 5A–D) for HT29DDP and HCT116-LOHP cells, respectively) showed that the apoptotic rates of different treatment groups were higher than those of the untreated control group; the difference between PTX-16nM group and the control group was statistically significant (P 0.05). The difference between combination therapy group (PTX-8nM + BEZ 50nM group and PTX-16nM + BEZ 50nM group) and the control group was also statistically significant (P 0.01). These data indicate that PTX combined with BEZ235 can more effectively promote apoptosis in drug-resistant colon cancer as compared with PTX alone. We then further analyzed the levels of Bcl-2 pr
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