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A 53-year-old woman presents to an emergency department in London after leaving her workplace due to what she describes as extremely severe and burning pain in her left upper abdomen, radiating to her left back. She explains that she has never experienced these symptoms before, nor has she had any previous acute illness requiring hospitalization.
Her past medical history includes indigestion and regurgitation, which her physician is investigating. Her family history offers no additional relevant information, and findings of a physical examination are unremarkable.
Her vital signs are within normal range, and findings of a general examination are unremarkable. However, palpation of her abdomen reveals a very tender, warm left hypochondrial region with hypersensitivity; there is no evidence of enlarged organs or visible skin lesions.
There s some room for improvement in diagnosing pediatric hidradenitis suppurativa (HS), researchers suggested.
In an international cross-sectional analysis of 481 patients diagnosed with HS, the average age of diagnosis came about 2 years after the average age of disease onset (14.4 and 12.5 years, respectively), according to Irene Lara-Corrales, MD, of the University of Toronto, and colleagues.
Among adolescents, the inflammatory skin condition most often presented with a cyst or abscess, accounting for about half of the first signs and symptoms, they stated in
The second and third most common initial symptoms of the debilitating disorder were pain and tenderness (25%), followed by papules and pustules (24%).
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Adding radiation therapy to standard treatment improved failure-free survival (FFS) and overall survival for prostate cancer patients with only a few bone metastases, an exploratory analysis of the multi-arm, multi-stage STAMPEDE trial found.
Among the nearly 2,000 men in the study, adding radiation to mostly androgen deprivation therapy (ADT) improved both FFS (HR 0.57, 95% CI 0.47-0.70) and overall survival (HR 0.62, 95% CI 0.46-0.83) in those with only non-regional lymph node metastasis or with fewer than three bone lesions and no visceral metastases, reported Noel Clarke, MBBS, of the Christie NHS Foundation Trust in Manchester, England, and colleagues.
Patients either with visceral metastasis or four or more bone lesions still had improved FFS (HR 0.87, 95% CI 0.76-0.99,
In prostate cancer, as in life, you roll the dice.
In craps, 3+3 is called a hard six. It s hard because you can only win if you repeat with a combination of 3+3. Any other sixes you roll 4+2, 5+1 are losers.
Gleason 3+3 is a hard six in prostate cancer. It is the lowest grade cancer in the traditional Gleason scoring system. Still, to the eye of a pathologist, a Gleason 6 looks like a malignancy.
Now, a few experts are questioning whether this hard six is a cancer at all. Some urologists see a Gleason 6 as a noncancerous growth that has the potential to be invasive, but most likely will never spread to other organs or end up killing a man.