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CAMBRIDGE, MA Boron, a metalloid element that sits next to carbon in the periodic table, has many traits that make it potentially useful as a drug component. Nonetheless, only five FDA-approved drugs contain boron, largely because molecules that contain boron are unstable in the presence of molecular oxygen.
MIT chemists have now designed a boron-containing chemical group that is 10,000 times more stable than its predecessors. This could make it possible to incorporate boron into drugs and potentially improve the drugs ability to bind their targets, the researchers say. It s an entity that medicinal chemists can add to compounds they re interested in, to provide desirable attributes that no other molecule will have, says Ron Raines, the Firmenich Professor of Chemistry at MIT and the senior author of the new study.
Chemists boost boron s utility
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Chemists boost boron s utility | MIT News | Massachusetts Institute of Technology
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