Elias Bou Farhat, MD, discusses an investigation of NGS sensitivity vs standard IHC alone in the assessment of dMMR colorectal cancer or endometrial cancer.
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Drs Nassar and Bou Farhat explain how tumor-only NGS could address the limitations of IHC testing for MMR mutation signatures across several tumor types.
Amin Nassar, MD, and Elias Bou Farhat, MD, spotlight a study evaluating the accuracy and sensitivity of NGS mutation signature in assessing MMR status vs IHC testing.
Immunotherapy, a highly effective treatment for patients whose cancers harbour mismatch repair deficiency, can also benefit endometrial and colon cancer patients.
Endometrial and colon cancer patients often have high rates of mismatch repair deficiency a genetic state where errors in DNA occur