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Operator: Greetings, and welcome to Fulcrum Therapeutics Fourth Quarter and Full Year 2022 Earnings Conference Call. As a reminder, this conference is being recorded.

United statesMatt bieglerAlan ezekowitzAcceleron pharmaRobertj gouldIain fraserMadhu kumarTed tenthoffMatthew bieglerEdward tenthoffPiper sandlerRobert gouldChris calabreseMatthew harrisonJudah frommerEsther rajavelu