Kaizer Chiefs will be looking to reach the Caf Champions League semi-finals while Simba SC are keen to make a comeback when the two sides clash in Dar es Salaam.
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Squads & Team News
Striker Samir Nurkovic is back after missing their final Champions League group match away at Horoya due to suspension.
The Serb was booked twice, resulting in a red card during their penultimate group game against Wydad Casablanca at home.
But goalkeeper Daniel Akpeyi remains suspended despite being sent off in the same match.
With Itumeleng Khune still recovering from a shoulder injury, this makes Bruce Bvuma likely to start in goal for a third game running in all competitions and he will be deputised by Brylon Petersen.
Chiefs have also been battling to have defender Erick Mathoho back from injury ahead of the Simba match while Khama Billiat is far from returning and could miss the rest of the season after aggravating his leg fracture.