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Edward Barnes dead | Blue Peter creator dies aged 92
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Edward Barnes: Tributes paid to Newsround creator
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Continued disparity among IBD diagnoses Source:
Barnes E, et al. Abstract 251. Presented at: Digestive Disease Week; May 21-23, 2021 (virtual meeting). Disclosures:
Barnes reports consulting for AbbVie, Gilead, Pfizer, Takeda ad Target RWE. Please see the study for all other authors’ relevant financial disclosures.
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EDITOR S NOTE:
There are not enough pages in a Sunday newspaper to mention every major Butte fire â from the city s infancy to present day. Suffice to say, the Mining City has had its fair share. Todayâs story and photographs feature several that have occurred throughout Butteâs history.
Butte firefighters worked from the early morning hours and all day on Friday as a fire gutted the iconic M&M Cigar Store in Uptown Butte. Meagan Thompson, The Montana Standard
The fire that destroyed the historic M&M Cigar Store on May 7 reminded us all that weâve been down this road before â many, many times. With the number of major fires Butte has sustained since its infancy, itâs truly a miracle the town has remained standing.
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Treatment with tofacitinib (Xeljanz) proved to be rapidly effective for moderate-to-severe ulcerative colitis (UC), even in patients who previously failed tumor necrosis factor (TNF) inhibition, post hoc analysis of trial data indicated.
While the oral small-molecule JAK inhibitor had greater efficacy than placebo for both induction and maintenance of remission, rates of herpes zoster (serious and non-serious) were numerically higher in tofacitinib recipients, regardless of previous response to TNF inhibition, reported William Sandborn, MD, of the University of California San Diego.
TNF inhibitor failure has been suggested as a predictor of poor prognosis in UC. Patients refractory to this therapy may be more challenging to treat, and therefore have an unmet need for alternative therapies.
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