These two "Group of Death" participants can progress with victory, while a draw could still be a positive result for each side as Japan take on Spain in their Group E finale.
The Netherlands will know that they are very nearly into the World Cup Round of 16, but they still have much to play for as they enter their final group stage match against hosts Qatar.
There should be familiar faces on show for Premier League fans when Uruguay and South Korea meet in their opening World Cup clash at Education City Stadium.