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Clip NIH Director s Blog On-the-Spot Gene Readouts Offer Clues to How Cells Work (March 11) | MIT News

Clip NIH Director s Blog On-the-Spot Gene Readouts Offer Clues to How Cells Work (March 11) | MIT News
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On-the-Spot Gene Readouts Offer Clues to How Cells Work

Posted on Credit: MIT and Harvard Medical School, Cambridge, MA Just as two companies can merge to expand their capabilities, two technologies can become more powerful when integrated into one. That’s why researchers recently merged two breakthrough technologies into one super powerful new method called ExSeq. The two-in-one technology enables researchers for the first time to study an intact tissue sample and track genetic activity on the spot within a cell’s tiniest recesses, or microenvironments areas that have been largely out of reach until now. ExSeq, which is described in a paper in the journal Science [1], will unleash many new experimental applications. Beyond enabling more precise analysis of the basic building blocks of life, these applications include analyzing tumor biopsies more comprehensively and even unlocking mysteries of how the brain works. The latter use is on display in this colorful cross-section of a mouse’s hippocam

United statesUnited kingdomMassachusetts institute of technologyFrancis collinsEd boydenGeorge churchGeorge church harvard medical schoolNational human genome research instituteSynthetic neurobiology group massachusetts institute of technologyHarvard medical schoolOn the spot gene readouts offer cluesHow cellsMassachusetts instituteNational human genome researchNeurobiology groupஒன்றுபட்டது மாநிலங்களில்

Cognito Therapeutics touts positive Phase 2 results for device-delivered Alzheimer s treatment

Cognito Therapeutics touts positive Phase 2 results for device-delivered Alzheimer s treatment
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Brent vaughanTom megerianEd boydenLi huei tsaiYesterday cognito therapeuticsCognito therapeuticsBreakthrough device designationDevice designationப்ரெண்ட் வாகன்எட் பாய்டன்அறிவாற்றல் சிகிச்சைதிருப்புமுனை சாதனம் பதவிசாதனம் பதவி

GenSight Biologics Announces the Publication in Communications Biology of the Proof-of-Concept for GS030-Drug Product in Non-Human Primates

GenSight Biologics Announces the Publication in Communications Biology of the Proof-of-Concept for GS030-Drug Product in Non-Human Primates The ex vivo retinal stimulation assays also showed that the electrophysiologic response of RGCs expressing ChrimsonR precisely followed the duration and frequency of the light pulses used to activate the opsin. Moreover, localized stimulation of RGCs induced a response coherent with the size and position of the light pulses. Optogenetic stimulation of RGCs expressing ChrimsonR-tdT can support restoration of visual acuity The electrophysiological activity of RGCs expressing ChrimsonR-tdT was consistent with the direction and speed of a moving stimulus. Furthermore, the spatiotemporal activation of treated retinas was specific to the shape of the moving symbols presented (square, circle, cross of different sizes), indicating the ability to discriminate between patterns. This level of pattern discrimination corresponded to a Snellen visual acu

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A high-resolution glimpse of gene expression in cells

Credits: Courtesy of the researchers Previous image Next image Using a novel technique for expanding tissue, MIT and Harvard Medical School researchers have devised a way to label individual molecules of messenger RNA within a tissue sample and then sequence the RNA. This approach offers a unique snapshot of which genes are being expressed in different parts of a cell, and could allow scientists to learn much more about how gene expression is influenced by a cell’s location or its interactions with nearby cells. The technique could also be useful for mapping cells in the brain or other tissues and classifying them according to their function.

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