Early initiation of HET in pediatric-onset MS was linked to slower progression to disability compared to treatment with low-efficacy therapy or no treatment.
With mounting research showing that physical activity affects brain volume, fatigue, and other outcomes, researchers are finding ways to have patients with multiple sclerosis be more active.
Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time.
Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whether admission date and other characteristics were associated with ICU admission or cardiac involvement.
Results: Of 232 children with MIS-C (median age 5.8 yr), 130 (56.0%) were male and 50 (21.6%) had comorbidities. Seventy-three (31.5%) patients were admitted to the ICU but none died. We observed an increased risk of ICU admission among children aged 13–17 years (adjusted risk difference 27.7%, 95% confidence interval [CI] 8.3% to 47.2%), those aged 6–12 years (adjusted risk difference
High serum levels of neurofilament light are associated with an increased risk for disease progression at 2 years. Clinical, MRI, and OCT measures are not associated with this risk, however.