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Selinexor/Ruxolitinib Combo Is Tolerable, Shows Durable Spleen, Symptom Responses in JAK Inhibitor–Naive Myelofibrosis

The oral XPO1 inhibitor selinexor in combination with ruxolitinib was associated with a tolerable and manageable adverse effect profile and elicited signals of clinical efficacy in patients with JAK inhibitor–naive myelofibrosis.

United statesSrinivask tantravahiUniversity of utah huntsman cancer instituteDynamic international prognostic scoring systemUtah huntsman cancer instituteSelinexor in combination with ruxolitinibPatients with jak inhibitor naive myelofibrosisXport mf 034 trialThe university of utah huntsman cancer institute

TP-3654 Demonstrates Favorable Tolerability, Early Clinical Activity in R/R Myelofibrosis

The oral selective PIM1 kinase inhibitor TP-3654 appeared to be well tolerated and to show early signals of spleen volume reduction, symptom improvement, and correlating cytokine reductions in patients with relapsed or refractory myelofibrosis, according to preliminary data.

North carolinaUnited statesDuke university medical centerDynamic international prognostic scoring systemMyelofibrosis symptom assessmentPim1 kinase inhibitorTp 3654Phase 1 2 tp 3654 102 study

Pacritinib could lead to OS benefit for patients with myelofibrosis with thrombocythemia

Pacritinib could lead to OS benefit for patients with myelofibrosis with thrombocythemia
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San diegoUnited statesHelen ajufoMindy valcarcelBydavid statmanJakafi incyteDynamic international prognostic scoring systemMemorial sloan kettering cancer centerDynamic international prognostic scoring

MorphoSys Pelabresib Improves All Four Hallmarks of Myelofibrosis in Phase 3 MANIFEST-2 Study

MorphoSys Pelabresib Improves All Four Hallmarks of Myelofibrosis in Phase 3 MANIFEST-2 Study
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United statesSan diegoUnited kingdomCity ofRaajitk rampalTim demuthJulia neugebauerRuben mesaEamonn nolanClaire harrisonThomas biegiEuropean medicines agencyConstellation pharmaceuticals incHilton san diego bayfront hotelLymphoma societyMyeloproliferative neoplasms program

MorphoSys: Phase 3 Study Of Pelabresib Combination In Myelofibrosis Meets Primary Endpoint

MorphoSys: Phase 3 Study Of Pelabresib Combination In Myelofibrosis Meets Primary Endpoint
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Rheinland pfalzMore such health newsEuropean medicines agencyDynamic international prognostic scoring systemNew drug applicationMarketing authorization applicationFast track