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Community Scoop » Heart Foundation Joins Forces With International Research Funding Group To Improve Global Heart Health

Press Release – The Heart Foundation Leading cardiovascular research funders, including the Heart Foundation, have joined forces in a new partnership to accelerate the prevention, diagnosis and treatment of the worlds biggest killers, heart disease and stroke. The new Global Cardiovascular … Leading cardiovascular research funders, including the Heart Foundation, have joined forces in a new partnership to accelerate the prevention, diagnosis and treatment of the world’s biggest killers, heart disease and stroke. The new Global Cardiovascular Research Funders Forum (GCRFF) unites 11 leading independent international organisations to coordinate funding for global clinical trials and promote international research efforts in heart, stroke and circulatory diseases.

United kingdomNew zealandUnited statesNew zealandersGerry devlinCharmaine griffithsHeart foundation is new zealandHeart foundationAmerican heart associationGerman centre for cardiovascular researchLeducq foundationNational heart foundation of australiaStroke association of canadaBritish heart foundationDutch heart foundationDanish heart foundation

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to secrete proinflammatory cytokines. Thus, altered antibody glycosylation may contribute to disease severity in COVID-19. Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that e

Noord hollandUnited statesMiltenyi biotecU cytech biosciencesMelinda gates foundationDutch federation of university medical centersInnovative medicines initiativeAmsterdam cardiovascular sciencesAgilent technologiesDutch heart foundationNetherlands organization for health researchEuropean unionGraphpad softwareDiscovery workbench softwareEuropean union horizonProinflammatory panel

Stores to price less healthy food higher for unique research project

Stores to price less healthy food higher for unique research project
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Noord hollandJosine stuberCarolien martensDutch heart foundationSupreme nudgeநூற்த் ஹாலண்ட்டச்சு இதயம் அடித்தளம்

Patients who are overweight or obese at risk of more severe COVID-19

E-Mail IMAGE: Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study. view more Credit: i yunmai Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study. The research, led by the Murdoch Children s Research Institute (MCRI) and The University of Queensland and published in Diabetes Care, found obese or overweight patients are at high risk for having worse COVID-19 outcomes. They are also more likely to require oxygen and invasive mechanical ventilation compared to those with a healthy weight.

South australiaUnited statesSouth africaDavidp burgnerGraham colditzJessicae millerSiroon bekkeringDanielle longmoreEdin mifsudYanshan zhuDavid burgnerDaniellek longmoreNational healthMonash universityUniversity of queenslandUniversity of queensland dr kirsty short

Opportunities to better detect, manage and treat patients with undiagnosed atrial fibrillation

E-Mail (Boston) Atrial fibrillation (AF) is associated with a higher risk of complications including ischemic stroke, cognitive decline, heart failure, myocardial infarction and death. AF frequently is undetected until complications such as stroke or heart failure occur. While the public and clinicians have an intense interest in detecting AF earlier, the most appropriate strategies to detect undiagnosed AF and medical prognosis and therapeutic implications of AF detected by screening are uncertain. A new report led by Boston University School of Medicine (BUSM) researcher Emelia J. Benjamin, MD, ScM, builds upon a recently conducted National Heart, Lung, and Blood Institute s virtual workshop that focused on identifying key research priorities related to AF screening.

United statesBoston universityUnited kingdomEmeliaj benjaminJeffrey olginStuart connollyVan gelderBristol myers squibbBristol meyers squibbBoehringer ingelheimBoston biomedical associatesDutch heart foundationSanofi aventisEuropean union horizonMcmaster universityCardiology research