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Antiepileptic Drug Holds Promise in Treating ALS by Angela Mohan on December 11, 2020 at 10:46 AM
Ezogabine reduces the excitability of cortical and spinal motor neuron cells and holds potential in treating amyotrophic lateral sclerosis (ALS), according to a study conducted by the Neurological Clinical Research Institute of Massachusetts General Hospital (MGH).
In addition to providing a clearer understanding of motor neuron excitability as an important disease pathway for ALS, the multi-site study, published in
JAMA Neurology, involves the first clinical investigation of ALS (also known as Lou Gehrig s disease) using a drug identified through an induced pluripotent stem cell (iPSC) model.