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Although crude mortality did not differ between variants, adjusted risk of death was
highest for patients treated with ECMO infected with the delta variant of SARS-CoV-2.
The higher virulence and poorer outcomes associated with the delta strain might relate
to higher viral load and increased inflammatory response syndrome in infected patients,
reinforcing the need for a higher rate of vaccination in the population and updated
selection criteria for ECMO, should a new and highly virulent strain of SARS-CoV-2
emerge in the future.
This Viewpoint describes the organization of a regional ICU network in Lombardy, Italy, to handle the surge in patients infected with severe acute respiratory s