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The eMendi Building, new headquarters of the Transnet National Ports Authority, is named after the SS Mendi.
More than 600 South African men - most of them black - died when the Mendi collided with the SS Darro in 1917.
The ports authority is relocating 221 employees from its two head offices in Durban and Johannesburg to the new building before 31 March.
The eMendi Building - the new headquarters of the Transnet National Ports Authority (TNPA) in Port of Ngqura in the Eastern Cape - commemorates the lives of the men who died when the SS Mendi sank more than 100 years ago.