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Whole Genome Sequencing Reveals 13 New Gene Variants in Alzheimer s Disease

In a genome-wide association study (GWAS), the genomes of many individuals are scanned in search of common gene variants that occur more frequently in people who have a given disease, such as Alzheimer’s disease (AD). However, common Alzheimer’s-associated gene variants have accounted for less than half of the heritability of AD. A standard GWAS misses the rare gene variants (those occurring in less than 1% of the population). Now researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center, report they have used whole genome sequencing (WGS) to discover rare genomic variants associated with AD, and have identified 13 variants.

United statesRudolph tanziDmitry prokopenkoBeth israel deaconess medical centerMccance centerBrain healthMassachusetts general hospitalChan schoolPublic healthCance centerஒன்றுபட்டது மாநிலங்களில்ருடால்ப் டான்சிபெத் இஸ்ரேல் டேப்ககோணேஸ் மருத்துவ மையம்ம்க்க்யாந்ஸ் மையம்மூளை ஆரோக்கியம்மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை

Scientists find 13 rare Alzheimer s gene variants

A new study highlights findings from sequencing more than 2,000 people’s genomes. By Story at a glance The genes associated with the disease affect the brain’s function and development. Researchers have identified rare gene variants associated with Alzheimer’s disease. Researchers have identified 13 variants of genes connected to Alzheimer’s disease that are new to scientists. In a study published in Alzheimer s & Dementia: The Journal of the Alzheimer s Association, the researchers report how they sequenced whole genomes of people in more than 600 families with individuals who have been diagnosed with Alzheimer’s and searched for rare versions of genes.

United statesRudolph tanziDmitry prokopenkoResearch unitHospital mccance centerJournal of the alzheimer associationBrain healthMassachusetts general hospitalMccance centerAging research unitAdd changing americaஒன்றுபட்டது மாநிலங்களில்ருடால்ப் டான்சிஆராய்ச்சி அலகுமருத்துவமனை ம்க்க்யாந்ஸ் மையம்இதழ் ஆஃப் தி முதுமறதி சங்கம்

First-of-its-kind study identifies 13 new Alzheimer s disease genes

First-of-its-kind study identifies 13 new Alzheimer’s disease genes In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer s disease (AD), researchers have identified 13 such variants (or mutations). In another novel finding, this study establishes new genetic links between AD and the function of synapses, which are the junctions that transmit information between neurons, and neuroplasticity, or the ability of neurons to reorganize the brain s neural network. These discoveries could help guide development of new therapies for this devastating neurological condition. Researchers at Massachusetts General Hospital (MGH), the Harvard T. H. Chan School of Public Health, and Beth Israel Deaconess Medical Center report these findings in

United statesRudolph tanziDmitry prokopenkoEmily hendersonResearch unitBeth israel deaconess medical centerMccance centerJournal of the alzheimer associationBrain healthMassachusetts general hospitalChan schoolPublic healthAging researchCance centerAlzheimer 39s diseaseMedical school

Thirteen new Alzheimer s genes identified in first-of-its-kind human genome study

Thirteen new Alzheimer s genes identified in first-of-its-kind human genome study
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United statesRudolph tanziDmitry prokopenkoResearch unitCure alzheimer fundBeth israel deaconess medical centerNational institutes of healthMccance centerJournal of the alzheimer associationBrain healthMassachusetts general hospitalChan schoolPublic healthAging researchCance centerHarvard medical school

13 new rare gene variants of Alzheimer s identified

13 new rare gene variants of Alzheimer s identified
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New yorkUnited statesRudolph tanziDmitry prokopenkoResearch unitMccance centerJournal of the alzheimer associationBrain healthMassachusetts general hospitalCance centerAgeing researchபுதியது யார்க்ஒன்றுபட்டது மாநிலங்களில்ருடால்ப் டான்சிஆராய்ச்சி அலகும்க்க்யாந்ஸ் மையம்