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Revealing HIV drug-resistance mechanisms through protein structures

Revealing HIV drug-resistance mechanisms through protein structures
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Researchers uncover molecular mechanisms of HIV drug resistance

Researchers uncover molecular mechanisms of HIV drug resistance
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Salk researchers uncover molecular mechanisms of HIV drug resistance

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV.

HIV drug resistance mechanisms revealed by protein structures: Study

HIV drug resistance mechanisms revealed by protein structures: Study
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Revealing HIV drug-resistance mechanisms thro

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV. Their findings reveal how changes to the 3D structures of integrase, an HIV protein, can lead to Dolutegravir resistance and how other compounds may be able to overcome this resistance.

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