Waiting more than 12 weeks for surgery following neoadjuvant therapy was associated with improved tumor regression grade and reduced risk of systemic recurrence but not overall survival.
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Neoadjuvant chemoradiotherapy can be omitted in low-risk rectal cancer patients without compromising outcomes, but intensified in high-risk patients, new findings suggest.
Patients with stage I-III rectal cancer typically undergo chemoradiation before surgery, but MRI can identify those who could skip this step and go straight to upfront surgery.
The results might be explained by "all patients in the VA dataset having insured access to health care, regardless of socioeconomic status," the authors wrote.