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A new mathematical model offers hope for better prediction and treatment of Alzheimer’s disease.  Most mathematical models of Alzheimer’s are theoretical, focusing on short term molecular and cellular-level changes that cannot be measured in patients. However, researchers at Duke University School of Medicine and Pennsylvania State University have used real-world data from over 800 people with varying cognitive abilities, to develop the Alzheimer’s Disease Biomarker Cascade (ADBC) model.  

Kashyap sreeramJeffreyr petrellaSophia dalzielWenrui haoJuliet jiangAlzheimer imaging research laboratoryDuke university school of medicineDepartment of defenseNational institutes of healthNational science foundationPennsylvania state universityAlzheimer disease neuroimaging initiativeDuke university schoolDisease biomarker cascadeImaging research laboratoryMurali doraiswamy