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Association between proteins may predict early MS disease activity

Association between proteins may predict early MS disease activity
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Multiple sclerosisPotential predictive biomarkerDisease activityNeurology neuroimmunology

Histological, Clinical Disease Activity Linked to Reduced Fertility in Women with IBD

Histological inflammation and clinical IBD activity were both associated with reduced fertility rates compared to histological remission and quiescent IBD.

Vastra gotalands lanUniversity of gothenburgInternational classification of diseaseInstitute of clinical sciences at sahlgrenska academySwedish national patient registerUniversity of gothenburg karlClinical sciencesSahlgrenska academySwedish prescribed drug registerInflammatory bowel diseaseUlcerative colitisCrohn x27s diseaseHistological inflammationDisease activity

Making Rheum for Biosimilars: Overcoming Reluctance

Despite the proven efficacy of biosimilars, both patients and health care providers often have some reluctance when switching from an originator drug to a biosimilar.

United statesAshley walshCenters for diseaseClinical drug investigationJoint disease activity scoreClinical disease activity indexSimplified disease activity indexMohegan pharmacyEight month monitoringDisease activityLong standing rheumatoid arthritis treatedClinical outcome predictionBiologic originatorClin drugDisease controlAccessed february

Higher Vitamin D Levels Pre-Methotrexate Linked to Lower Mortality in RA

After adjusting for risk factors, patients in the > 50 nmol/L pre-methotrexate initiation group exhibited a 28% reduced risk of mortality when compared with those in the ≤ 50 nmol/L group

Shahdik malakootiB association between vitamind deficiencyVeterans affairsHealth assessment questionnaire disability indexCase western reserve university school of medicineMetrohealth systemDisease activity scoreCase western reserve university schoolCox proportional hazard modelVitamind levelsMethotrexate therapy initiation are associatedLower subsequent mortalityAutoimmunity the immune systemBetween vitamind deficiencyDisease activityRadiographic progression

Obesity Linked to Increased Disease Activity in ACPA-Positive Rheumatoid Arthritis

Patients with ACPA-positive RA and obesity had greater DAS44 scores compared to normal-weight patients, although this difference was not present in ACPA-negative RA.

Henk van steenbergenHollandern kdUs centers for diseaseLeiden universityDisease controlCognitive psychologyLeiden early arthritis clinicHelm van milDisease activityTreatment responseCurr rheumatolRheumatoid arthritisBody mass indexDisease activity scoreAcpa positiveAcpa negative