New research combined sophisticated genetically engineered mouse models and advanced computational methods to map the earliest cell states leading to pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer.
Researchers have used senescent cells as a "vaccine" that can be used as a prophylaxis and a therapeutic to prime the immune system against cancer cells, which has shown positive results in cancer models.
• Researchers at IRB Barcelona report that the induction of senescence in tumour cells strongly stimulates the immune system.
• Vaccination with sene..
Cancer cells have a series of features that allow the immune system to identify and attack them. However, these same cells create an environment that blocks immune cells and protects the tumor.
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