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Research showed that screening 10-year-old adolescents who are at high risk of type 1 diabetes (T1D) for islet autoantibodies could predict future development of T1D.
Since the 1980s, we have been gaining knowledge about the pathogenesis of type 1 diabetes
and found that the measurement of diabetes-associated autoantibodies against insulin,
glutamic acid decarboxylase, insulinoma-associated protein 2, and zinc transporter
8 has a central role in recognition of early stages of the disease in asymptomatic
people. In the 1990s, large prospective studies were established in Finland (the Diabetes
Prediction and Prevention [DIPP] study1), Germany (the BABYDIAB study2), Sweden (Diabetes
Prediction in Skåne Study3), and the USA (the Diabetes Autoimmunity Study in the Young
[DAISY]4) that followed up children with a high genetic risk of developing type 1
diabetes from birth until diagnosis of clinical type 1 diabetes.