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Study gives insight into cause of severe infl

Cedars-Sinai investigators have identified a genetic variant that increases people’s risk of developing perianal Crohn’s disease, the most debilitating manifestation of Crohn’s disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections.

Genetic Variant Linked with Severe Manifestation of Crohn s Disease

Gut Troubles

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