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With new variants and a changing landscape of vaccination and immunity, what do the symptoms of covid-19 and our understanding of them now look like? Mun-Keat Looi reports In the short space of a few years we’ve seen surprising changes in the way covid-19 presents. At the start of the pandemic the first commonly reported symptoms were loss of smell and taste, followed by shortness of breath and a cough, followed by vascular injuries, says David Strain, senior clinical lecturer at the University of Exeter Medical School. “That became the standard that we expected,” he says. Betty Raman, senior clinical research fellow in the Radcliffe Department of Medicine, University of Oxford, says, “People presenting with the earlier variants would have quite severe cardiorespiratory or mostly respiratory symptoms in the acute phase with other symptoms too, like brain fog. Quite a significant proportion were admitted to hospital with the earlier variants.” Since then there’s been an e

United kingdomUnited statesBetty ramanTim spectorMun keat looiMonica verduzco gutierrezUniversity of exeter medical schoolUniversity of oxfordDepartment of rehabilitation medicineWorld health organizationLong school of medicineRadcliffe department of medicineDavid strainExeter medicalRadcliffe departmentHealth organization