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Scientists Uncover Kill Switch to Obliterate Cancerous Tumors Internally

UC Davis Cancer Center scientists have uncovered a 'kill switch' within the CD95 receptor, offering potential breakthroughs in cancer treatment and enhanced CAR T-cell therapy for solid tumors.

Jogender tushir singhJohn lopezUniversity of notre dameUc davis comprehensive cancer centerAmerican cancer society getty imagesDepartment of medical microbiologyTech timesComprehensive cancer centerDaily mailCell deathAmerican cancerGetty imagesMedical microbiologyNotre dame

Epitope Identified That Activates Cancer Cell Death

Epitope Identified That Activates Cancer Cell Death
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Jogender tushir singhUc davis comprehensive cancer centerDepartment of medical microbiologyComprehensive cancer centerCell deathMedical microbiology

Researchers discover new way to trigger programmed cell death in cancer cells

A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.

Arjun singhMegan craigSophial aleixoMatthewr watsonBriceen wambaGary scott leiserowitzSalvatore condelloTanmoy mondalJogender tushir singhRoland fallerSanchita bhatnagarIndiana university school of medicineDepartment of medical microbiologyUc davis comprehensive cancer centerComprehensive cancer centerCell death

Researchers identify switch to activate cancer cell death

Researchers identify switch to activate cancer cell death
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Arjun singhSalvatore condelloSanchita bhatnagarBriceen wambaGary scott leiserowitzMatthewr watsonJogender tushir singhSophial aleixoRoland fallerTanmoy mondalDepartment of medical microbiologyIndiana university school of medicineMedical microbiologyHimanshu gaurAbby grace michalakCamryn stout

Researchers identify switch to activate can

<p>A research team from the UC Davis Comprehensive Cancer Center has identified a crucial mechanism on a specific cell receptor that can cause cells to self-destruct. Being able to activate the receptor—Fas—and trigger cell death could open the door for improved cancer treatments. Modulating Fas may also extend the benefits of chimeric antigen receptor (CAR) T-cell therapy to solid tumors.</p>

Jogender tushir singhMatthewr watsonSalvatore condelloGary scott leiserowitzBriceen wambaSanchita bhatnagarArjun singhRoland fallerSophial aleixoTanmoy mondalMethod of researchIndiana university school of medicineUc davis comprehensive cancer centerDepartment of medical microbiologyComprehensive cancer centerCell death