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Randomized Controlled Trial Suggests Metformin Offers Benefits During Pregnancy
Researchers randomly assigned 502 pregnant women with type 2 diabetes who were using insulin to add metformin (1,000 milligrams twice daily) or a placebo to their treatment regimen.
As women neared the end of pregnancy, at 34 weeks’ gestation, the participants on metformin had lower average fasting blood sugar levels than their counterparts who didn’t take metformin (41.0 versus 43.2 millimoles per mol) and used less insulin (1.1 units versus 1.5 units per kilogram [kg] per day).
With metformin, women also gained less weight than participants on placebo (7.2 versus 9.0 kg), and were also 15 percent less likely to require a cesarean delivery and 42 percent less likely to have a baby that was large for its gestational age, in the 97th percentile for birth weight.