Damian Di Florio, Ph.D., remembers the lightning-bolt moment five years ago when he began thinking differently about the questions scientists ask. He was a summer undergraduate student working in the
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June 03, 2021
A novel microRNA measured in plasma, first discovered in mice and then isolated in humans for the first time, eventually might provide a simpler way to diagnose acute myocarditis, a preliminary study suggests.
Expressed by type 17 helper T (Th17) lymphocytes, levels of the microRNA accurately distinguished patients with acute myocarditis from those with acute MI, with an area under the receiver-operating-characteristic curve (AUC) of 0.927, according to researchers led by Rafael Blanco‑Domínguez, MSc, and Raquel Sánchez‑Díaz, PhD (both National Center for Cardiovascular Research, Madrid, Spain).
The biomarker’s ability to identify patients with acute myocarditis was confirmed through comparisons with other groups of patients, as well, including those with MI with nonobstructive coronary arteries (MINOCA) and a variety of autoimmune diseases, the investigators report in a study published in the May 27, 2021, issue of the