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In one of the largest studies of its kind, researchers provide answers to whether COVID-19 vaccinations reduce sickness and mortality following infection with SARS-CoV-2. The study published today in The Lancet Microbe found among individuals recently infected with SARS-CoV-2, those who were fully vaccinated had lower concentrations of almost all inflammation markers (cytokines and chemokines) than those who were unvaccinated in the short-term and long-term after symptomatic SARS-CoV-2 infection. While vaccinations don’t entirely prevent infection, this study demonstrates that vaccination significantly reduces morbidity and mortality by significantly reducing elevated levels of cytokines and chemokines that are correlated with a higher risk of severe infection. “Our research demonstrates the long-term benefits of the COVID-19 vaccines to reduce inflammation even after a breakthrough infection,” said co-author Alison Abraham, PhD, MS, MHS, associate professor of epidemiology

United statesJoshua xianming zhuAaron tobianDepartment of defenseUs armyUniversity of colorado anschutz medical campusColorado school of public healthJohns hopkins university school of medicineUchealth university of colorado hospitalNuclear defenseUniversity of coloradoDefense health agencyLancet microbeColorado schoolPublic healthColorado anschutz medical