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Enlarged fluid-filled spaces around cerebral small blood vessels were linked to cognitive decline, a prospective study of older adults showed.
Severe perivascular space pathology in both the basal ganglia and the centrum semiovale, or in the centrum semiovale alone, was tied to a greater drop in global cognition over 4 years, reported Matthew Paradise, MBChB, MSc, of the University of New South Wales in Sydney, Australia, and co-authors.
Large perivascular space dilation in both brain regions was an independent predictor of dementia across 8 years of follow-up (adjusted OR 2.91, 95% CI 1.43-5.95,
P=0.003), with stronger effects at either year 4 or 6, the researchers wrote in