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<p>A novel gene therapy for hearing loss was administered to six children in China in a clinical trial co-led by investigators at Mass Eye and Ear in Boston and Eye & ENT Hospital of Fudan University in Shanghai, China. Each child had an inherited deafness caused by mutations in the <em>OTOF </em>gene<em>,</em> called DFNB9. The researchers report in a new study in <em>The Lancet</em>, after 26 weeks, five children demonstrated hearing recovery and dramatic improvements in speech perception and the restored ability to conduct normal conversation. With its first patient treated in December 2022, this research represents the first human clinical trial to administer gene therapy for treating this form of hearing loss, with the most patients treated and longest follow-up conducted to date.</p>
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Mengzhao-xun
Jiajia-zhang
Kaiyu-gao
Huawei-li
Longlong-zhang
Renjie-chai
Jinghan-wang
Luoying-jiang