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Batch testing for SARS-CoV-2 Frequent and accurate RT-PCR–based testing is essential for preventing and managing SARS-CoV-2 infection; however, active infection surveillance is still often limited by time or resources. Cleary et al. demonstrate that considering population-level viral prevalence and individual viral loads allows for efficiency gains upon pooled testing with minimal loss of sensitivity, both theoretically and as validated in vitro using human swab and sputum samples. Barak et al. show that pooled testing of 133,816 hospital-collected patient nasopharyngeal samples eliminated three quarters of testing reactions with only a minor reduction in sensitivity, demonstrating the efficacy of the approach in the field. Both studies suggest that considered pooling of individual samples before testing could reliably increase SARS-CoV-2 testing throughput.

Hebrew universityIsrael generalHa afonYutti daitchIrit fogelGil benedekDanag wolfRoni benT miriam rohrlichEsther oiknine djianAyalah livnehE chabube kripperAdi sabataniD ben zviMila rivkinHadassah medical center