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WINSTON-SALEM, N.C. - May 16, 2021 - Heart failure (HF) - when the heart can t pump enough blood and oxygen through the body - affects approximately 6.2 million adults in the United States and is the primary cause of hospitalization in the elderly. Unfortunately, older adults with heart failure often have poor outcomes resulting in reduced quality of life, high mortality and frequent rehospitalizations.
Despite many efforts to improve the prognosis in these patients, most previous studies testing a wide range of interventions were not successful.
Scientists from the Wake Forest, Duke University and Thomas Jefferson schools of medicine tried a different approach - tailoring rehabilitation treatment to the individual and beginning it while the patient was still recovering in the hospital, which is not standard care for these older HF patients.
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High-intensity interval training (HIIT) did not beat traditional exercise in raising exercise capacity for sedentary patients with heart failure with preserved ejection fraction (HFpEF), according to the OptimEx-Clin trial.
HIIT and moderate continuous training groups yielded similar improvements in peak oxygen consumption (VO
2) from baseline to 3 months (+1.1 vs +1.6 mL/kg/min) both too modest to meet a prespecified minimal clinically-important threshold in comparison with controls (-0.6 mL/kg/min).
Neither HIIT nor traditional exercise remained associated with improved exercise capacity at 12 months compared with controls, who got no supervised exercise training, only guideline-directed advice on physical activity, reported Martin Halle, MD, of the Technical University of Munich, Germany, and colleagues online in