Newly discovered biomarker like natural killer T cells exhibit a distinct pattern in COVID-19, which acknowledges severe symptoms and helps in prompt treatment planning
Human blood contains several different components, including plasma, red blood cells (RBCs), white blood cells (WBCs), and platelets. Among these, WBCs are divided into numerous subcategories each with unique functions and characteristics, such as lymphocytes, monocytes, neutrophils, and others.
Study suggests T-cells don t determine survival in severe COVID-19
The coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes mild to moderate illness in the general population. Some people, however, may experience severe symptoms, which can be potentially fatal.
Severe COVID-19 has been tied to T cell lymphopenia, but no causal effect of T cell deficiency on disease severity has been established.
Researchers at the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health found that T cell-depleted groups of rhesus macaques developed virus-neutralizing antibody responses and also class-switched to immunoglobulin G (IgG).
Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?
The extent of severity of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), varies from asymptomatic, mild to severe. Scientists found that during the first wave of the pandemic, individuals infected with non-severe SARS-CoV-2, before the onset of the vaccination program, induced effective host-defense mechanisms in naive populations.
To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. Scientists believe that understanding the early immune response regarding the asymptomatic or mildly infected population may help determine the factors associate
Beckman Coulter Life Sciences launches next-generation CytoFLEX SRT benchtop cell sorter
Mar 4 2021
Leading the way for more than 85 years, Beckman Coulter Life Sciences proudly announces the launch of its highly anticipated CytoFLEX SRT Benchtop Sorter the CytoFLEX that sorts, and features expanded laser and color options for use in labs of all sizes.
Image credit: Beckman Coulter Life Sciences
This new addition to the CytoFLEX Platform builds on the principles of the CytoFLEX, which make multicolor applications accessible. The software experience will be very familiar, further increasing the ease-of-use right out of the box. It now boasts new technologies to automate and simplify sort setup and stream maintenance, bringing the power of single-cell analysis to more laboratories.