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Direct challenges recommended for most antibiotic allergy evaluations

Physicians should perform graded direct challenges when patients at low risk for a reaction report an antibiotic allergy, according to a review published in Annals of Allergy, Asthma & Immunology. In addition to improving clinical outcomes, these challenges often provide cost and time savings compared with skin testing, Allison C. Ramsey, MD, allergy and clinical immunology, Rochester

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