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Cell adaptation in critically ill could be difference between life and death

The study showed that the cells of people who survived critical illness (ie two or more organs failing) produced energy in a different way to those who did not survive. The behaviour of critically ill cells looks similar to how cells adapt to limited oxygen levels (hypoxia). The work took place before the COVID-19 pandemic, but findings are relevant to patients on ventilators experiencing low oxygen levels or multiple organ failure.

Study of COVID-19 in Ireland shows links between underlying conditions and poorer outcomes

 E-Mail Monday, 26 April 2021: A national study of 20,000 patients conducted by RCSI University of Medicine and Health Sciences and the HSE Health Protection Surveillance Centre (HPSC) has identified the underlying conditions that are associated with more severe outcomes from COVID-19 in an Irish setting. The research, which has been published in The Lancet Regional Health - Europe, will help inform national public health policies and assist in future treatment and prevention strategies for people at most risk from the virus. The study, which took place during the first wave of the pandemic between March and July 2020, is the first national surveillance study in Ireland that captures data from both hospital and community settings. Data was collected by HPSC for almost 20,000 confirmed cases of COVID-19. The association between underlying conditions and more severe outcomes from COVID-19 was examined, including mortality, admission to hospital or admission to ICU.

Shift-work causes negative impacts on health, affects men and women differently

 E-Mail Shift-work and irregular work schedules can cause several health-related issues and affect our defence against infection, according to new research from the University of Waterloo. These health-related issues occur because the body s natural clock, called the circadian clock, can be disrupted by inconsistent changes in the sleep-wake schedule and feeding patterns often caused by shift work. To study this, researchers at Waterloo developed a mathematical model to look at how a disruption in the circadian clock affects the immune system in fighting off illness. Because our immune system is affected by the circadian clock, our ability to mount an immune response changes during the day, said Anita Layton, professor of Applied Mathematics, Computer Science, Pharmacy and Biology at Waterloo. How likely are you to fight off an infection that occurs in the morning than midday? The answer depends on whether you are a man or a woman, and whether you are among quarter of the mode

Two distinct types of COVID-19-associated acute respiratory distress syndrome identified

 E-Mail BOSTON - Approximately one in four patients hospitalized for the acute respiratory distress syndrome (ARDS) associated with severe COVID-19 infections may have a distinct phenotype (disease presentation) or biochemical profile associated with organ dysfunction, blood-clotting abnormalities and greater risk of death than patients with other, seemingly similar forms of the disease, researchers at Massachusetts General Hospital (MGH) have found. Among 263 patients admitted to intensive care units (ICUs) at MGH for respiratory failure due to severe COVID-19 infection, 70 (26.6%) had increased levels of biomarkers in the bloodstream indicating disordered blood clotting, higher inflammation, and organ dysfunction compared with the other patients, report Sylvia Ranjeva MD, PhD, and Lorenzo Berra, MD, investigators in the Department of Anesthesia, Critical Care and Pain Medicine, and their colleagues in that department and Pulmonary and Critical Care Medicine and Respiratory Care

Lundquist investigator Chang s study in JAMA Internal Medicine

 E-Mail IMAGE: Lundquist Investigator Dr. Dong Chang and his colleagues study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study - Evaluation of Time-Limited Trials Among. view more  Credit: Courtesy of The Lundquist Institute LOS ANGELES (April 13, 2021) The Lundquist Institute (TLI) Investigator Dong W. Chang, MD, and his colleagues study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study - Evaluation of Time-Limited Trials Among Critically Ill Patients with Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments - found that training physicians to communicate with family members of critically ill patients using a structured approach, which promotes shared decision-making, improved the quality of family meetings. This intervention was associated with reductions in invasive ICU treatments that prolonged suffering without benefit for patients and their

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