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A non-covalent inhibitor of 3C-like protease effectively inhibits SARS-CoV-2 replication

Researchers assessed highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro.

Cristian moga shutterstockImage creditMiddle eastCoronavirus disease covid 19Ars cov 2Binding affinityCovid 19Magnetic beadsErs covEvere acute respiratoryEvere acute respiratory syndrome

What are the hidden sources of SARS-CoV-2 evolution?

A recent article published in Transplant Infectious Disease examined case reports on SARS-CoV-2 evolution in immunosuppressed cohorts.

Cristian moga shutterstockTransplant infectious diseaseTransplant infectious diseasesCoronavirus disease covid 19Ars cov 2Covid 19Monoclonal antibodyIbonucleic acidEvere acute respiratoryEvere acute respiratory syndrome

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

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Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

Cristian moga shutterstockCoronavirus disease covid 19Ars cov 2Flow cytometryHuman leukocyte antigenEvere acute respiratoryEvere acute respiratory syndrome

Novel approach estimates past SARS-CoV-2 daily infections, cumulative infections, and the proportion of the population infected

In a recent study published in The Lancet, the authors estimated the global, national, and regional daily and cumulative SARS-CoV-2 infections.

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