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Risk Factors Could Inform BTK Inhibitor and Venetoclax Sequencing in CLL/SLL

Changchun Deng, MD, PhD, discusses factors to consider when sequencing covalent BTK inhibitors and venetoclax in patients with CLL/SLL.

United statesOncology program at case comprehensive cancer centerUniversity hospitals seidman cancer centerChangchun dengImmune oncology programCase comprehensive cancer centerCovalent btk inhibitorsChronic lymphocytic leukemia cllSmall lymphocytic lymphoma

Treatment Resistance with Covalent BTKis: Translating Data into Clinical Practice

Javier Pinilla, MD, PhD explores evidence on molecular mechanisms leading to resistance in second-generation BTK inhibitors for CLL, providing insights from recently presented data at ASH 2023.

Javier pinillaExploring therapeutic advancementsChronic lymphocytic leukemiaTranslating dataCovalent btkisCovalent btk inhibitorsBtk inhibitorsTreatment resistanceCll treatmentChronic lymphocytic leukemia treatment

Head-to-Head Studies on BTK Inhibitors in CLL

CLL expert Lori A. Leslie, MD, gives a comprehensive overview of the ALPINE and ELEVATE-RR head-to-head studies of BTK inhibitors in CLL.

Gloria leslieChronic lymphocytic leukemiaCovalent btk inhibitorsElevate rrDel 11qDel 17pProgression free survivalToxicity profileAlpine studyOverall responseAsh 2022 annual meeting

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