Autophagy‐activating Peptide Reduces Acne and Improves Barrier Function March 15, 2021 Contact Author Michele Behrens
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Journal of Cosmetic Dermatology was published that sought to investigate the potential benefits of a topically applied autophagy-activating peptide for the treatment of acne.
This research is based on recent studies published that cited the important role of autophagy signaling in sebaceous lipogenesis and epidermal differentiation.
Researchers examined the clinical efficacy of the peptide through an 8 week, double‐blind, randomized, vehicle‐controlled study. The effects of the peptide on sebaceous lipogenesis were measured by fluorescence microscopic analysis. Autophagy signaling in human immortalized SZ95 sebocytes, normal human epidermal keratinocytes and 3D reconstituted skin was examined. The researchers also analyzed changes in skin surface lipid compositions.