Neurocrine Biosciences Receives Breakthrough Therapy Designation From U S Food And Drug Administration For Crinecerfont In Congenital Adrenal Hyperpl
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Neurocrine Biosciences Receives Breakthrough Therapy Designation from U S Food and Drug Administration for Crinecerfont in Congenital Adrenal Hyperplasia
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Individuals that live in groups experience different challenges based on their social rank and sex. Glucocorticoids have a well-established role in coordinating responses to challenges and glucocorticoid levels often vary between ranks and sexes. However, the neuroendocrine mechanisms regulating glucocorticoid dynamics in wild groups are poorly understood, making it difficult to determine the functional consequences of differences in glucocorticoid levels. Therefore, we observed wild social groups of a cooperatively breeding fish (Neolamprologus pulcher) and evaluated how scale cortisol content (an emerging method to evaluate cortisol dynamics in fishes) and expression of glucocorticoid-related genes varied across group members. Scale cortisol was detectable in ~50% of dominant males (7/17) and females (7/15) but not in any subordinates (0/16) suggesting that glucocorticoid levels were higher in dominants. However, the apparent behavioural and neuroendocrine factors regulating cortisol