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Credit: Covadonga Vara and Aurora Ruiz-Herrera, UAB. The genome is tightly organised (packaged) within the cell nuclei. This three-dimensional (3D) genome organisation is fundamental, given that it regulates gene expression. A study led by scientists at the Universitat Autònoma de Barcelona (UAB) now demonstrates using mice models that the 3D organisation of the genome is extremely dynamic during the formation of male germ cells (precursors of spermatozoa) and that alterations in this structure can affect fertility. The research, published in Nature Communications, describes the 3D genome organisation in germ cells of wild populations of house mice (Mus musculus domesticus) with chromosomal rearrangements, alterations in the genome which change the structure of chromosomes. The study represents a significant advance in research into mechanisms generating and regulating the structure and function of the genome during the formation of gametes (oocytes and sperm).

Comunidad autonoma de catalunaCovadonga varaAurora ruiz herreraNature communicationsDepartment of cellular biologyNational centre for genomic analysisCentre for genomic regulationInstitute of biotechnologyCornell university united statesDepartment of animal biologyUniversitat autAssociated professorCellular biologyAnimal biologyPlant biologyNational centre