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Surrey cyclist s 5,000-mile challenge inspired by barefoot walk

Surrey cyclist s 5,000-mile challenge inspired by barefoot walk Published image captionJosh Garman will be towing his self-made camper around the British coastline A man is taking on a 5,000-mile (8,000km) cycle challenge after being inspired by a father s barefoot walk. Josh Garman, 22, from Milford near Guildford, is planning on cycling the coast of Great Britain starting in Berwick-upon-Tweed. He will be pulling a self-made camper weighing about eight stone (50kg) which he will be sleeping in throughout. Mr Garman said he was inspired by Maj Chris Brannigan s 700-mile (1,126km) walk in aid of his daughter s charity. The Hope for Hasti charity is named after Maj Brannigan s eight-year-old daughter who has the rare genetic condition Cornelia de Lange Syndrome (CdLS).

Gene critical to immune cell development identified

Date Time Gene critical to immune cell development identified Much of the three-dimensional architecture of the genome in antibody-producing immune cells is dependent on a gene called SMC3. When this gene is not working properly it can lead to improper immune cell development and to cancer, by disrupting how DNA is structured inside the cell nucleus, according to a team of researchers from Weill Cornell Medicine. Victoria Béguelin/Provided The two canvases represent the genome as folded in cells with normal (left) or reduced levels of SMC3. The normal canvas is highly structured and functional, while the other canvas has lost its pattern and has open threads.

New Genetic Disorder Affects Brain and Craniofacial Skeleton

New Genetic Disorder Affects Brain and Craniofacial Skeleton by Angela Mohan on  January 22, 2021 at 12:10 PM New genetic disorder is characterized by developmental delays and malformations of the brain, heart and facial features. Named linkage-specific-deubiquitylation-deficiency-induced embryonic defects syndrome (LINKED), the disorder is caused by a mutated version of the OTUD5 gene, that affects the key molecular steps in embryo development. The findings indicate that the newly identified pathway may be essential for human development and may also underlie other disorders that are present at birth. The information will help scientists better understand such diseases both common and rare and improve patient care. The results were reported in

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